Donghui Zhang*1, Genling Yang†1, Xidong Li‡, Cheng Xu*, Honglei Ge§
Oncology Research, Vol.23, No.4, pp. 171-181, 2015, DOI:10.3727/096504016X14519995067562
Abstract Cullin7 is an E3 ubiquitin ligase. The Cullin7 protein family functions as a molecular scaffold to coordinate
substrate ubiquitination in Skp, Cullin, and F-box-containing complex (SCF complex). Cullin7s control normal
development and primary cellular processes and are characterized by a unique genomic network organization.
Less is known about the involvement of Cullin7 with hepatocellular carcinoma (HCC). In this study, we found
that Cullin7 showed a high expression in HCC tumor tissues, especially in metastatic HCC tumor tissues. Also,
there was a negative correlation between Cullin7 expression and long survival. Silencing of Cullin7 in liver
cancer More >
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