Xuguang Wang*, Zhe Chen†
Oncology Research, Vol.24, No.4, pp. 271-277, 2016, DOI:10.3727/096504016X14666990347473
Abstract Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase complexes, was found to be
overexpressed in many types of tumors. However, the expression pattern and role of CUL4B in non-small cell
lung cancer (NSCLC) remain largely unknown. Therefore, in the present study, we investigated the role of
CUL4B in NSCLC, and the underlying mechanism was also explored. Our results showed that CUL4B was
highly expressed in NSCLC cell lines. Silencing CUL4B obviously inhibited proliferation and migration/invasion of NSCLC cells, and it also suppressed the epithelial–mesenchymal transition (EMT) progress in NSCLC
cells. Furthermore, knockdown More >
Login
Register
