Ruifang Zeng, Guolin Tan, Wei Li, Yanhong Ma
Oncology Research, Vol.26, No.1, pp. 111-122, 2018, DOI:10.3727/096504017X14924753593574
Abstract This study aimed to investigate the clinical significance of cullin 3 expression in nasopharyngeal carcinoma
(NPC), as well as to explore the regulatory mechanism of cullin 3 underlying the growth and metastasis of
NPC cells. Our findings showed that the expression levels of cullin 3 were significantly increased in both NPC
tissues and cell lines. A strong positive correlation was found between cullin 3 expression and the Ki-67-based
proliferation index in NPC tissues. Moreover, cullin 3 overexpression was correlated with local relapse and
distant metastasis in NPC patients. In vitro experiments showed that knockdown of More >
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