Azik Hoffman^1,2,*, Eyal Kochavi³, Gilad E. Amiel^1,2

Canadian Journal of Urology, Vol.32, No.5, pp. 423-432, 2025, DOI:10.32604/cju.2025.064740 - 30 October 2025

Abstract Objectives: Initial treatment for Non-Muscle Invasive Bladder Cancer (NMIBC) has remained mostly unchanged in recent decades. Cryotherapy with CO₂ has been commonly used in medicine for many years. In this study, we present the results of a pre-clinical study aimed at developing a novel cryoablation device to treat superficial low-grade bladder lesions. Methods: Following initial technical and developmental studies, a rigid cryotherapy device was developed. A technical and efficacy assessment was conducted utilizing the porcine model. Overall, twenty-six ablation areas (up to four per animal) were evaluated. Following an initial routine cystoscopy, the bladder irrigation medium… More >

Rafi Mazor^1,*, Meital Mazor², Ali E. Dabiri^2,3, Bhavesh Patel², Ghassan S. Kassab²

Molecular & Cellular Biomechanics, Vol.17, No.2, pp. 93-99, 2020, DOI:10.32604/mcb.2019.08267

Abstract Cryotherapy, or more commonly known as cold therapy, is the use of low temperatures in medical treatment. The most prominent use of cryotherapy is for cryosurgery where application of very low temperatures is used to ablate diseased tissue (e.g., most commonly in dermatology). Recent research, however, shows that low temperature may modulate collagen fibers beyond the already known effects of extreme cooling on joint pain relieve and inflammation. The goal of this brief review is to outline the known effects of extreme cooling on molecular, fiber and cell physiology and to leverage these properties in… More >

David M. Marcus^1,5, Daniel J. Canter^2,5, Ashesh B. Jani^1,2,5, Ryan W. Dobbs², David M. Schuster³, Bradley C. Carthon^4,5, Peter J. Rossi^1,2,5

Canadian Journal of Urology, Vol.19, No.6, pp. 6534-6541, 2012

Abstract Introduction: External beam radiotherapy (EBRT) is widely utilized as primary therapy for clinically localized prostate cancer. For patients who develop locally recurrent disease after EBRT, local salvage therapy may be indicated. The primary modalities for local salvage treatment in this setting include radical prostatectomy, cryotherapy, and brachytherapy. To date, there is little data describing outcomes and toxicity associated with each of these salvage modalities.
Materials and methods: A review of the literature was performed to identify studies of local salvage therapy for patients who had failed primary EBRT for localized prostate cancer. We focused on prospective trials… More >

Eric Winquist, Mary J. Mackenzie, George Rodrigues

Canadian Journal of Urology, Vol.15, No.4, pp. 4147-4152, 2008

Abstract Introduction: Given the improved therapeutic efficacy and acceptable side effect profile with current cryotechnology, we wish to better understand the attitudes of community urologists expressing interest in this treatment modality toward the adoption of cryotherapy in their practice.
Methods: A retrospective survey was conducted with information gathered on 50 responding physicians who attended a cryosurgery workshop between February 2004 and September 2006. Specifics such as demographics and professional background, reasons for interest in cryosurgery, and the current status of cryosurgery in the physicians' practice were collected and analyzed using SPSS, version 14 (Chicago, IL).
Results: Of the responding… More >

Michael Eng¹, Liam Taylor², Marja Verhoef², Scott Ernst³, Bryan Donnelly⁴

Canadian Journal of Urology, Vol.12, No.2, pp. 2607-2613, 2005

Abstract Background: To date, few two-arm active treatment randomized control trials (RCTs) have compared prostate cancer therapies.
Objective: To examine the difference and similarities between the reasons for accepting and declining participation in a two-arm active treatment RCT comparing external beam radiation therapy (EBRT) versus cryotherapy.
Methods: Eleven men with prostate cancer, selected purposively, participated in a 30-minute post-treatment semi-structured interview. Interviews were transcribed verbatim, coded and analyzed for patterns with the assistance of the text management (TM) software (NVivo).
Results: RCT accepters participated principally with the hope of being randomized into the cryotherapy treatment arm. Consequently, randomization into the More >

Tom Pickles¹, S. Larry Goldenberg², Gary Steinhoff¹

Canadian Journal of Urology, Vol.12, No.2, pp. 2593-2597, 2005

Abstract Introduction and objective: High-Intensity Focused Ultrasound (HIFU) is a technology that has moved from being used for benign prostate disease to the treatment of prostate cancer. A technology review was undertaken to guide patients and physicians as to its suitability.
Method: An evidence-based review of published papers in the English language, with additional material from internet and other sources.
Results and conclusions: Only case series have been published; there are no randomized studies. The quality of evidence is poor, with no reports having longer follow-up than a mean of 2 years, with median follow-ups substantially shorter. Efficacy outcomes are More >