YUSHI YANG^1,#, CHUJIAO HU^2,#, SHAN LEI³, XIN BAO³, ZHIRUI ZENG^3,*, WENPENG CAO^4,*

Oncology Research, Vol.32, No.12, pp. 1921-1934, 2024, DOI:10.32604/or.2024.046191 - 13 November 2024

Abstract Background: The heterogeneity of prognosis and treatment benefits among patients with gliomas is due to tumor microenvironment characteristics. However, biomarkers that reflect microenvironmental characteristics and predict the prognosis of gliomas are limited. Therefore, we aimed to develop a model that can effectively predict prognosis, differentiate microenvironment signatures, and optimize drug selection for patients with glioma. Materials and Methods: The CIBERSORT algorithm, bulk sequencing analysis, and single-cell RNA (scRNA) analysis were employed to identify significant cross-talk genes between M2 macrophages and cancer cells in glioma tissues. A predictive model was constructed based on cross-talk gene expression, and… More >

DURGA KORA¹, ANANYA DEY¹, BABITA PAL¹, UTHPAL KRISHNA ROY^1,2, NIVEDITA DEY¹, TREESHA BHATACHARJEE¹, SOUMEN BHATTACHARJEE^1,*

BIOCELL, Vol.47, No.3, pp. 503-521, 2023, DOI:10.32604/biocell.2023.025744 - 03 January 2023

Abstract The elaborate redox network of the cell, comprising of events like turnover of reactive oxygen species (ROS), redox sensing, signaling, expression of redox-sensitive genes, etc., often orchestrates with other bonafide hormonal signaling pathways through their synergistic or antagonistic action in the plant cell. The redox cue generated in plant cells under fluctuating environmental conditions can significantly influence other hormonal biosynthetic or signaling mechanisms, thereby modulating physiology towards stress acclimation and defense. There is also strong evidence of the recruitment of ROS as a ‘second messenger’ in different hormonal signaling pathways under stress. Moreover, the retrograde… More >

LI YANG^1,2, KUN DENG³, ZHIQIANG MOU^1,2, PINGFU XIONG^1,2, JIAN WEN^1,2, JING LI^1,2,*

Oncology Research, Vol.30, No.5, pp. 243-258, 2022, DOI:10.32604/or.2022.027958 - 03 February 2023

Abstract Background: Considering the great heterogeneity of Hepatocellular carcinoma (HCC), more accurate prognostic models are urgently needed. This paper combined the advantages of genomics and pathomics to construct a prognostic model. Methods: First, we collected data from hepatocellular carcinoma patients with complete mRNA expression profiles and clinical annotations from the TCGA database. Then, based on immune-related genes, we used random forest plots to screen prognosis-related genes and build prognostic models. Bioinformatics was used to identify biological pathways, evaluate the tumor microenvironment, and perform drug susceptibility testing. Finally, we divided the patients into different subgroups according to the… More >

Lei Zhang^*, Dejian Yang, Lei Ren, Yun Cheng, Qiufeng Yan, Yinlong Yuan

Energy Engineering, Vol.118, No.4, pp. 1155-1170, 2021, DOI:10.32604/EE.2021.014549 - 31 May 2021

Abstract As a wide bandgap power electronics device, the SiC MOSFET has a lot of advantages over the traditional Si IGBT. Replacing the Si IGBT with the SiC MOSFET in the existing power electronics converter is an effective means to improve the performance and promote the upgrading of the traditional converter. Generally, in order to make full use of its advantages of the SiC MOSFET, the Si IGBT in the traditional power electronics circuit cannot be simply replaced by the SiC MOSFET, but the main circuit and the driver circuit need to be redesigned because the… More >

Buentello Volante¹ B, F Díaz de León-Sánchez¹, F Rivera-Cabrera¹, R Aguilar Caballero², M Ponce-Valadez¹, E Sánchez de Jiménez², LJ Pérez-F lores¹

Phyton-International Journal of Experimental Botany, Vol.79, pp. 101-108, 2010, DOI:10.32604/phyton.2010.79.101

Abstract Auxin and insulin promote Zea mays embryo growth, induce S6 ribosomal protein (S6rp) phosphorylation, and promote specific protein synthesis. The objective of this research was to test a possible cross-talk between insulin and auxin transduction pathways in Z. mays coleoptiles, typical auxin target tissues. Auxin and insulin produced differential quantitative and qualitative stimulation of cytoplasmic and ribosomal protein phosphorylation, and specific patterns of de novo synthesized cytoplasmic proteins. In addition, insulin induced S6rp phosphorylation was strongly inhibited by rapamycin, indicating target of rapamycin (TOR) kinase participation; auxin-induced S6rp phosphorylation was insensitive to this inhibitor. Phosphatidic acid (PA), a More >