Huijie Jia*†1, Tiesuo Zhao‡§1, Di Zou¶, Xiaolong Jia§, Ji Gao#, Xiangfeng Song‡§
Oncology Research, Vol.23, No.6, pp. 321-326, 2015, DOI:10.3727/096504016X14570992647041
Abstract Synthetic CpG oligodeoxynucleotides (ODNs), as TLR9 agonists, have been found to play a possible role in
antitumor effect. In order to determine the effect of YW002, known as a C-type CpG ODN, on the treatment of
hepatocellular carcinoma (HCC), which is one of the most aggressive carcinomas, we chose to inject YW002 at
the doses of 12.5 μg and 25 μg per mouse 7 days post-tumor challenge. The survival rate of mice was recorded
every day. On day 14 postinjection, five mice in each group were bled and randomly sacrificed. The level of
IFN-γ or… More >
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