Roberta Milani*, Eleonora Brognara*, Enrica Fabbri*, Alessia Finotti*, Monica Borgatti*, Ilaria Lampronti*, Giovanni Marzaro†, Adriana Chilin†, Kenneth Ka-Ho Lee‡, Stanton Hon-Lung Kok‡, Chung-Hin Chui§, Roberto Gambari*
Oncology Research, Vol.26, No.9, pp. 1307-1315, 2018, DOI:10.3727/096504017X14928634401187
Abstract Glioblastoma multiforme (GBM), a malignant tumor of the central nervous system, has a high mortality rate.
No curative treatment is presently available, and the most commonly used chemotherapeutic drug, the alkylating agent temozolomide (TMZ), is only able to increase life expectancy and is often associated with drug
resistance. Therefore, an urgent need does exist for novel drugs aimed at treating gliomas. In the present study,
we obtained three major results using corilagin: (a) demonstrated that it inhibits the growth of U251 glioma
cells through activation of the apoptotic pathway; (b) demonstrated that it is also More >
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