Jiunn-Wei Wang1,2,3, Wen-Hung Hsu2,3,4, Fang-Jung Yu2,3, Fu-Chen Kuo5, Chung-Jung Liu3,6, Chao-Hung Kuo1,2,3, Jaw-Yuan Wang7,8, Ming-Hong Lin9,*, Deng-Chyang Wu1,2,3,*
Oncology Research, Vol.33, No.12, pp. 3907-3922, 2025, DOI:10.32604/or.2025.070432
- 27 November 2025
Abstract Objectives: Colorectal adenomatous polyps frequently recur after removal and are precursors to colorectal cancer, highlighting the need for effective preventive strategies. This study evaluated the efficacy of probiotic Clostridium butyricum MIYAIRI 588 (CBM588) in preventing colorectal adenoma recurrence in high-risk patients. Methods: We conducted a randomized, single-blind, two-year crossover trial in patients with a history of adenomatous polyps. Participants received CBM588 in either the first or second year, with the alternate year as observation, and underwent annual surveillance colonoscopies. Outcomes (adenoma recurrence and polyp counts) were analyzed by intention-to-treat (ITT) and per-protocol (PP) approaches. Results: A total… More >
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