Feng Shuai^*, Bo Wang^†, Shuxiao Dong^‡

Oncology Research, Vol.26, No.7, pp. 1113-1121, 2018, DOI:10.3727/096504018X15166199939341

Abstract miR-522-3p is known to degrade bloom syndrome protein (BLM) and enhance expression of other proto-oncogenes, leading to tumorigenesis. This study aimed to investigate the molecular mechanisms of miR-522-3p in human colorectal cancer (CRC) cells. Expressions of miR-522-3p in CRC and adjacent tissues, as well as in normal human colon epithelial cell line (FHC) and five CRC cell lines, were detected. Human CRC cell lines, HCT-116 and HT29, were transfected with miR-522-3p mimic, inhibitor, or scrambled controls. Then cell viability, apoptosis, cell cycle progression, and the expressions of c-myc, cyclin E, CDK2, and BLM were assessed.… More >

Hüseyin Engin¹, Yücel Üstündağ², İshak Özel Tekin³, Ayla Gökmen⁴, Şehmuz Ertop⁴, Sevil Uygun İlikhan⁵

European Cytokine Network, Vol.23, No.2, pp. 68-71, 2012, DOI:10.1684/ecn.2012.0308

Abstract Background/Aim: despite the rapidly accumulating histopathological data reporting differences in the expression of members of the angiopoietin family on the surface of various normal and tumour cells, data for these growth factors in plasma from cancer patients, including colon cancer, are scarce. The aims of the present study were to measure the plasma concentrations of Ang-1, Ang-2 and Tie-2 in colon cancer patients, and to assess the correlation between the concentrations of these factors and the stage of the tumor. Patients and methods: the study cohort included 36 patients (18 male, 18 female) with colon… More >

Nicolas Muruve

Canadian Journal of Urology, Vol.10, No.2, pp. 1815-1818, 2003

Abstract Introduction: Total pelvic exenteration (TPE) is the standard of care for locally advanced colorectal cancer. This is a morbid procedure often leaving the patient with two ostomy sites and an extended recovery. Bladder preservation with complete tumor resection is often possible in these cases and we set out to determine if limited resection of the GU tract was as effective in tumor control as TPE.
Materials and methods: This is a retrospective review of all patients over a 7-year period with colorectal tumors invading the urinary system. These patients were divided into two groups based upon the… More >