Feng Shuai*, Bo Wang†, Shuxiao Dong‡
Oncology Research, Vol.26, No.7, pp. 1113-1121, 2018, DOI:10.3727/096504018X15166199939341
Abstract miR-522-3p is known to degrade bloom syndrome protein (BLM) and enhance expression of other proto-oncogenes, leading to tumorigenesis. This study aimed to investigate the molecular mechanisms of miR-522-3p
in human colorectal cancer (CRC) cells. Expressions of miR-522-3p in CRC and adjacent tissues, as well as
in normal human colon epithelial cell line (FHC) and five CRC cell lines, were detected. Human CRC cell
lines, HCT-116 and HT29, were transfected with miR-522-3p mimic, inhibitor, or scrambled controls. Then
cell viability, apoptosis, cell cycle progression, and the expressions of c-myc, cyclin E, CDK2, and BLM were
assessed.… More >
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