LIJUN JIANG1, WENMIN JI1, YAJIE GONG2, JIAJUN LI2, JINCHUN LIU1,*
BIOCELL, Vol.47, No.8, pp. 1803-1810, 2023, DOI:10.32604/biocell.2023.029516
- 28 August 2023
Abstract Background: Colorectal cancer (CRC) is one of the most common malignancies. Early diagnosis is the key to
effective treatment of CRC. Since microRNAs (miRNAs) can be used as biomarkers of CRC, the objective of this work was
to examine the effect of miR-520f-3p, which targets YAP1 (Yes-associated protein 1), on the ability of CRC cells to
proliferate, invade, migrate, and undergo epithelial-mesenchymal transition (EMT). Methods: A miR-520f-3p mimic
was used to overexpress miR-520f-3p in HT29 cells. To establish the tumor-bearing mouse model, transfected HT29
cells were subcutaneously implanted into BALB/c-nu nude mice, and YAP1 and miR-520f-3p… More >
Graphic Abstract
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