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  • Open Access

    ARTICLE

    LncRNA HOTAIR promotes DNA damage repair and radioresistance by targeting ATR in colorectal cancer

    HAIQING HU1,#,*, HAO YANG2,#, SHUAISHUAI FAN3, XUE JIA3, YING ZHAO3, HONGRUI LI3

    Oncology Research, Vol.32, No.8, pp. 1335-1346, 2024, DOI:10.32604/or.2024.044174

    Abstract Long non-coding RNAs (lncRNAs) have been implicated in cancer progression and drug resistance development. Moreover, there is evidence that lncRNA HOX transcript antisense intergenic RNA (HOTAIR) is involved in colorectal cancer (CRC) progression. The present study aimed to examine the functional role of lncRNA HOTAIR in conferring radiotherapy resistance in CRC cells, as well as the underlying mechanism. The relative expression levels of HOTAIR were examined in 70 pairs of CRC tumor and para-cancerous tissues, as well as in radiosensitive and radioresistant samples. The correlations between HOTAIR expression levels and clinical features of patients with… More >

  • Open Access

    ARTICLE

    Quantitative and Qualitative Responses of Hydroponic Tomato Production to Different Levels of Salinity

    Khalid A. Al-Gaadi1,2, Ahmed M. Zeyada1, ElKamil Tola2,*, Abdullah M. Alhamdan1,3, Khalid A.M. Ahmed3,4, Rangaswamy Madugundu2, Mohamed K. Edrris2

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1311-1323, 2024, DOI:10.32604/phyton.2024.049535

    Abstract From economic and nutritional points of view, tomato is, historically, considered one of the most important crops. Without significant yield reduction, most commercial cultivars of tomato crops are sensitive to moderate levels of salinity. However, high levels of salt stress can negatively affect the yield and quality of tomato fruits. Therefore, this study was conducted to evaluate the yield and fruit quality of three tomato cultivars (Forester, Ghandowra-F1, and Feisty-Red) cultivated hydroponically, under three different levels of nutrient solution salinity. Evaluation of tomato fruits was performed based on quantity (number and weight of fruits, and… More >

  • Open Access

    ARTICLE

    OPA3 overexpression modulates lipid droplet production and sensitizes colorectal cancer cells to bevacizumab treatment

    HONGBIAO WU*, DONGFANG LIU

    BIOCELL, Vol.48, No.6, pp. 971-980, 2024, DOI:10.32604/biocell.2024.049466

    Abstract Background: Colorectal cancer (CRC) represents a substantial risk to public health. Bevacizumab, the first US FDA-approved antiangiogenic drug (AAD) for human CRC treatment, faces resistance in patients. The role of lipid metabolism, particularly through OPA3-regulated lipid droplet production, in overcoming this resistance is under investigation. Methods: The protein expression pattern of OPA3 in CRC primary/normal tissues was evaluated by bioinformatics analysis. OPA3-overexpressed SW-480 and HCT-116 cell lines were established, and bevacizumab resistance and OPA3 effects on cell malignancy were examined. OPA3 protein/mRNA expression and lipid droplet-related genes were measured with Western blot and qRT-PCR. OPA3… More > Graphic Abstract

    OPA3 overexpression modulates lipid droplet production and sensitizes colorectal cancer cells to bevacizumab treatment

  • Open Access

    ARTICLE

    5-Fluorouracil dose escalation generated desensitized colorectal cancer cells with reduced expression of protein methyltransferases and no epithelial-to-mesenchymal transition potential

    KIMBERLY FENECH1, ISAAC MICALLEF1,2, BYRON BARON1,*

    Oncology Research, Vol.32, No.6, pp. 1047-1061, 2024, DOI:10.32604/or.2024.049173

    Abstract Background: Colorectal cancer (CRC) is one of the most frequently diagnosed cancers. In many cases, the poor prognosis of advanced CRC is associated with resistance to treatment with chemotherapeutic drugs such as 5-Fluorouracil (5-FU). The epithelial-to-mesenchymal transition (EMT) and dysregulation in protein methylation are two mechanisms associated with chemoresistance in many cancers. This study looked into the effect of 5-FU dose escalation on EMT and protein methylation in CRC. Materials and Methods: HCT-116, Caco-2, and DLD-1 CRC cell lines were exposed to dose escalation treatment of 5-FU. The motility and invasive potentials of the cells before… More > Graphic Abstract

    5-Fluorouracil dose escalation generated desensitized colorectal cancer cells with reduced expression of protein methyltransferases and no epithelial-to-mesenchymal transition potential

  • Open Access

    ARTICLE

    Transformation of MRI Images to Three-Level Color Spaces for Brain Tumor Classification Using Deep-Net

    Fadl Dahan*

    Intelligent Automation & Soft Computing, Vol.39, No.2, pp. 381-395, 2024, DOI:10.32604/iasc.2024.047921

    Abstract In the domain of medical imaging, the accurate detection and classification of brain tumors is very important. This study introduces an advanced method for identifying camouflaged brain tumors within images. Our proposed model consists of three steps: Feature extraction, feature fusion, and then classification. The core of this model revolves around a feature extraction framework that combines color-transformed images with deep learning techniques, using the ResNet50 Convolutional Neural Network (CNN) architecture. So the focus is to extract robust feature from MRI images, particularly emphasizing weighted average features extracted from the first convolutional layer renowned for… More >

  • Open Access

    ARTICLE

    Knockdown of RCN1 contributes to the apoptosis of colorectal cancer via regulating IP3R1

    XUAN SHI1,2, YUFEN WANG1, CHENYU LI1, WANGSHU FU3, XINYUE ZHANG3, AIXIA GONG1,*

    BIOCELL, Vol.48, No.5, pp. 835-845, 2024, DOI:10.32604/biocell.2024.048076

    Abstract Background: The incidence of colorectal cancer (CRC) has been increasing in recent years. Thus, the discovery of factors that can assist in alleviating CRC is urgently warranted. Methods: To identify a potential factor involved in the development of CRC, we screened the upregulated genes in tumor tissues through four datasets from an online database. The expression of reticulocalbin 1 (RCN1), a Ca-binding protein, was upregulated in the four datasets. Based on loss-of-function experiments, the effect of RCN1 on cell viability was assessed by Cell Counting Kit-8 (CCK-8) assay. The regulatory effect of RCN1 on apoptosis… More > Graphic Abstract

    Knockdown of RCN1 contributes to the apoptosis of colorectal cancer via regulating IP3R1

  • Open Access

    ARTICLE

    HCSP-Net: A Novel Model of Age-Related Macular Degeneration Classification Based on Color Fundus Photography

    Cheng Wan1, Jiani Zhao1, Xiangqian Hong2, Weihua Yang2,*, Shaochong Zhang2,*

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 391-407, 2024, DOI:10.32604/cmc.2024.048307

    Abstract Age-related macular degeneration (AMD) ranks third among the most common causes of blindness. As the most conventional and direct method for identifying AMD, color fundus photography has become prominent owing to its consistency, ease of use, and good quality in extensive clinical practice. In this study, a convolutional neural network (CSPDarknet53) was combined with a transformer to construct a new hybrid model, HCSP-Net. This hybrid model was employed to tri-classify color fundus photography into the normal macula (NM), dry macular degeneration (DMD), and wet macular degeneration (WMD) based on clinical classification manifestations, thus identifying and… More >

  • Open Access

    ARTICLE

    Analysis of Color Landscape Characteristics in “Beautiful Village” of China Based on 3D Real Scene Models

    Yiyi Cen1,3, Wenzheng Jia2, Wen Dai3,*, Chun Wang4, He Wu1

    Revue Internationale de Géomatique, Vol.33, pp. 93-109, 2024, DOI:10.32604/rig.2024.050273

    Abstract Color, as a significant element of village landscapes, serves various functions such as enhancing aesthetic appeal and attractiveness, conveying emotions and cultural values. To explore the three-dimensional spatial characteristics of color landscapes in beautiful villages, this study conducted a comparative experiment involving eight provincial-level beautiful villages and eight ordinary villages in Jinzhai County. Landscape pattern indices were used to analyze the color landscape patterns on the facades of these villages, complemented by a quantitative analysis of color attributes using the Munsell color system. The results indicate that (1) Natural landscape colors in beautiful villages are… More >

  • Open Access

    ARTICLE

    Unsupervised Color Segmentation with Reconstructed Spatial Weighted Gaussian Mixture Model and Random Color Histogram

    Umer Sadiq Khan1,2,*, Zhen Liu1,2,*, Fang Xu1,2, Muhib Ullah Khan3,4, Lerui Chen5, Touseef Ahmed Khan4,6, Muhammad Kashif Khattak7, Yuquan Zhang8

    CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3323-3348, 2024, DOI:10.32604/cmc.2024.046094

    Abstract Image classification and unsupervised image segmentation can be achieved using the Gaussian mixture model. Although the Gaussian mixture model enhances the flexibility of image segmentation, it does not reflect spatial information and is sensitive to the segmentation parameter. In this study, we first present an efficient algorithm that incorporates spatial information into the Gaussian mixture model (GMM) without parameter estimation. The proposed model highlights the residual region with considerable information and constructs color saliency. Second, we incorporate the content-based color saliency as spatial information in the Gaussian mixture model. The segmentation is performed by clustering… More >

  • Open Access

    ARTICLE

    Analysis of large datasets for identifying molecular targets in intestinal polyps and metabolic disorders

    SHAN OU#, YUN XU#, QINGLAN LIU, TIANWEN YANG, WEI CHEN, XIU YUAN, XIN ZUO, PENG SHI*, JIE YAO*

    BIOCELL, Vol.48, No.3, pp. 415-429, 2024, DOI:10.32604/biocell.2024.046178

    Abstract Background: The interrelation between intestinal polyps, metabolic syndrome (MetS), and colorectal cancer (CRC) is a critical area of study. This research focuses on pinpointing potential molecular targets to understand the link between intestinal polyp formation, metabolic irregularities, and CRC progression. Methods: We examined clinical samples from patients with intestinal polyps coexisting with MetS and compared them with samples from patients with standard intestinal polyps. Transcriptome sequencing and public database analysis were employed to identify significant pathways and genes. These targets were then validated through immunohistochemistry (IHC). Following the RNA interference of key target expression, a… More > Graphic Abstract

    Analysis of large datasets for identifying molecular targets in intestinal polyps and metabolic disorders

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