Xue-fei Jin, Hai Li, Shi Zong, Hong-yan Li
Oncology Research, Vol.24, No.6, pp. 477-485, 2016, DOI:10.3727/096504016X14685034103716
Abstract Collagen triple helix repeat containing-1 (CTHRC1), a secreted glycoprotein, is frequently upregulated in
human cancers. However, the functional role of CTHRC1 in renal cell carcinoma (RCC) remains unclear. Thus,
the aim of this study was to explore the role of CTHRC1 in RCC. Our results demonstrated that CTHRC1 was
upregulated in RCC tissues and cell lines. Knockdown of CTHRC1 significantly inhibits the proliferation in
RCCs. Furthermore, knockdown of CTHRC1 significantly inhibited the epithelial-to-mesenchymal transition
(EMT) process in RCCs, as well as suppressed RCC cell migration and invasion. Mechanistically, knockdown of
CTHRC1 inhibited the expression of More >
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