Jianpeng Liu*, Wei Li†, Shunshun Liu*, Xu Zheng*, Lin Shi*, Weitao Zhang*, Hongfa Yang*
Oncology Research, Vol.25, No.2, pp. 225-232, 2017, DOI:10.3727/096504016X14732772150587
Abstract Collagen triple helix repeat containing 1 (CTHRC1), an extracellular matrix-related protein, has been found
to be upregulated in many solid tumors and contributes to tumorigenesis. We found that CTHRC1 is overexpressed in glioblastoma tissues and cells. By using the technique of RNA interference, the expression of
CTHRC1 in the human glioblastoma U-87MG cell line was downregulated, and the proliferation and migration of U-87MG cells were examined. The results showed that the knockdown of CTHRC1 exerts inhibitory
effects on the proliferation and migration ability of U-87MG cells. Knockdown of CTHRC1 expression in
U-87MG cells resulted in More >
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