Shilei Wang*, Yuzuo Hui*, Xiaoming Li†, Qingbin Jia*
Oncology Research, Vol.26, No.8, pp. 1143-1154, 2018, DOI:10.3727/096504017X14965095236521
Abstract Gliomas are the most common primary brain tumors with high mortality. The treatment for gliomas is largely
limited due to its uncomprehending pathological mechanism. Here we aimed to investigate the effect of long
noncoding RNA (lncRNA) coiled-coil domain-containing 26 (CCDC26) in glioma progression. In our study,
the expression of CCDC26 was found upregulated in glioma tissues and cell lines compared with normal tissues
and cell lines. Further exploration detected decreased cell proliferation and increased cell apoptosis in U-251
and M059J cells transfected with CCDC26-siRNA. In addition, the silencing of CCDC26 strongly reduced the
wound closing… More >
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