DAWEI ZHU1,#, LEI ZHANG1,#, XIAOKAI SHI1, SHENGLIN GAO1, CHUANG YUE1, LIFENG ZHANG1, YU BAI1, QIFENG WANG2, ATSUSHI OKADA3, TAKAHIRO YASUI3, CHAO WANG1,4, XINGANG CUI4,5,*, LI ZUO1,*
Oncology Research, Vol.29, No.3, pp. 159-174, 2021, DOI:10.32604/or.2022.03458
- 01 August 2022
Abstract Identifying prognostic indicators of clear cell renal cell carcinoma (ccRCC) and elucidating the mechanisms
underlying ccRCC progression are crucial for improving ccRCC patient prognosis. This study investigated the clinical
significance and biological role of Ring finger protein 43 (RNF43) in ccRCC. Two independent cohorts of patients with
ccRCC were employed to determine the prognostic significance of RNF43 by immunohistochemistry and statistical
analyses. In vitro and in vivo experiments, RNA-seq, and other techniques were used to determine the biological role of
RNF43 in ccRCC and related molecular mechanisms. RNF43 expression was commonly decreased in ccRCC specimens,
and low… More >
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