Yi Long Wan*, Han Jue Dai†, Wei Liu‡, Hai Tao Ma*
Oncology Research, Vol.26, No.4, pp. 637-644, 2018, DOI:10.3727/096504017X15112639918174
Abstract Claudin18 (CLDN18) is necessary for intercellular junctions and is reported to be involved in cell migration and
metastasis, making it like an oncogene in various cancer types. However, the biological function and regulatory
mechanisms of CLDN18 in lung adenocarcinoma are not yet clear. In this study, we found downregulation of
miR-767-3p and upregulation of CLDN18 in lung adenocarcinoma tissue and cell lines. In addition, there was
a negative correlation between the expression of miR-767-3p and CLDN18 in lung adenocarcinoma. Double
luciferase reporter gene analysis showed that miR-767-3p modulates the expression of CLDN18 by binding its More >
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