JUNZHE YI^1,#, BINBIN LI^2,#, XIAOMIN YIN³, LINGRUI LIU¹, CAILU SONG¹, YING ZHAO⁴, MANBO CAI³, HAILIN TANG¹, DONG CHEN^4,*, NING LYU^1,*

Oncology Research, Vol.32, No.6, pp. 1129-1139, 2024, DOI:10.32604/or.2024.047524

Abstract Circular RNAs (circRNAs) have been recognized as pivotal regulators in tumorigenesis, yet the biological functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma (HCC) remain elusive. We sought to unveil the expression profile and biological role of circMYBL2 in HCC. Initial microarray analyses were conducted to probe the expression profile of circMYBL2 in HCC cells, and qRT‒PCR analysis was then performed in HCC cell lines and tissues, revealing significant upregulation of circMYBL2. Subsequent experiments were conducted to evaluate the biological function of circMYBL2 in HCC progression. Furthermore, bioinformatics analysis, qRT‒PCR… More >

XIAOJIA HUANG^1,#, CAILU SONG^2,#, JINHUI ZHANG², LEWEI ZHU^3,*, HAILIN TANG^2,*

Oncology Research, Vol.32, No.2, pp. 241-249, 2024, DOI:10.32604/or.2023.046582

Abstract Breast cancer has surpassed lung cancer to become the most common malignancy worldwide. The incidence rate and mortality rate of breast cancer continue to rise, which leads to a great burden on public health. Circular RNAs (circRNAs), a new class of noncoding RNAs (ncRNAs), have been recognized as important oncogenes or suppressors in regulating cancer initiation and progression. In breast cancer, circRNAs have significant roles in tumorigenesis, recurrence and multidrug resistance that are mediated by various mechanisms. Therefore, circRNAs may serve as promising targets of therapeutic strategies for breast cancer management. This study reviews the More >