Fajri Marindra Siregar^1,2, Sofia Mubarika Haryana³, Dyah Wulan Anggrahini⁴, Lucia Kris Dinarti⁴, Anggoro Budi Hartopo^4,*

Congenital Heart Disease, Vol.19, No.4, pp. 375-388, 2024, DOI:10.32604/chd.2024.054742 - 31 October 2024

Abstract A particular type of endogenous noncoding RNAs known as circular RNAs (circRNAs) has now become possible biomarkers for several diseases because of their stability and tissue-specific expression patterns. CircRNAs might play a role in various of biological processes. The identification of particular circRNAs dysregulated in pulmonary arterial hypertension (PAH) raises the possibility of these molecules serving as biomarkers for the disease’s early diagnosis and treatment. This review mainly summarizes the role and potential of circRNA as a future biomarker in PAH related to congenital heart disease. This study presented several potential circRNA targets as diagnostic More > Graphic Abstract

YE ZHANG¹, YANAN LIANG², YAN WU², LIWEN SONG², ZUWANG ZHANG^2,*

Oncology Research, Vol.32, No.11, pp. 1747-1763, 2024, DOI:10.32604/or.2024.030945 - 16 October 2024

Abstract Background: Papillary thyroid cancer (PTC) is the most prevalent histological type of differentiated thyroid malignancy. Circular RNAs (circRNAs) have been implicated in the pathogenesis and progression of various cancers. circTIAM1 (hsa_circ_0061406) is a novel circRNA with aberrant expression in PTC. However, its functional roles in PTC progression remain to be investigated. Methods: The expression levels of circTIAM1 in the PTC and the matched para-cancerous tissues were detected by quantitative real-time reverse-transcription PCR (qRT-PCR). The subcellular localization of circTIAM1 was examined by fluorescence in-situ hybridization (FISH). Kaplan-Meier plot was used to analyze the association of clinicopathological features… More >

Ambareen Khan¹, Sher Afghan Khan², Mohammed Nishat Akhtar^1,*, Abdul Aabid^3,*, Muneer Baig³

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.9, pp. 2007-2028, 2024, DOI:10.32604/fdmp.2024.049368 - 23 August 2024

Abstract When better fuel-air mixing in the combustion chamber or a reduction in base drag are required in vehicles, rockets, and aeroplanes, the base pressure control is activated. Controlling the base pressure and drag is necessary in both scenarios. In this work, semi-circular ribs with varying diameters (2, 4, and 6 mm) positioned at six distinct positions (0.5D, 1D, 1.5D, 2D, 3D, and 4D) inside a square duct with a side of 15 mm are proposed as an efficient way to apply the passive control technique. In-depth research is done on optimising rib size for various More > Graphic Abstract

Elif Çaloğlu Büyükselçuk^*

CMC-Computers, Materials & Continua, Vol.80, No.1, pp. 715-746, 2024, DOI:10.32604/cmc.2024.052509 - 18 July 2024

Abstract Industrial Internet of Things (IIoT) service providers have become increasingly important in the manufacturing industry due to their ability to gather and process vast amounts of data from connected devices, enabling manufacturers to improve operational efficiency, reduce costs, and enhance product quality. These platforms provide manufacturers with real-time visibility into their production processes and supply chains, allowing them to optimize operations and make informed decisions. In addition, IIoT service providers can help manufacturers create new revenue streams through the development of innovative products and services and enable them to leverage the benefits of emerging technologies… More >

Adelya Khayrova^*, Sergey Lopatin, Valery Varlamov

Journal of Renewable Materials, Vol.12, No.5, pp. 923-950, 2024, DOI:10.32604/jrm.2024.050033 - 17 July 2024

Abstract Due to the expected rise in the world population, an increase in the requirements for quality and safety of food and feed is expected, which leads to the growing demand for new sources of sustainable and renewable protein. Insect protein is gaining importance as a renewable material for several reasons, reflecting its potential contributions to sustainability, resource efficiency, and environmental conservation. Some insect species are known to be able to efficiently convert organic waste into high-value products such as protein, requiring less land and water compared to traditional livestock. In addition, insect farming produces fewer… More > Graphic Abstract

GUIBIN ZHONG^1,2,#, SHURONG WANG^3,#, YUJIN HE⁴, DAMING FENG¹, KE WEI¹, YANQIU YANG¹, JIANWEI CHEN^1,2,*, JUNLING CHEN^1,*

BIOCELL, Vol.48, No.6, pp. 1001-1008, 2024, DOI:10.32604/biocell.2024.050294 - 10 June 2024

Abstract Background: Hypertrophy of the ligamentum flavum (HLF) is a common contributor to spinal stenosis which results in significant neurological impairments. Circular RNA (circRNA) circ_0003609 has been linked to HLF; however, the exact mechanism by which it causes this disease is unclear. Methods: Circ_0003609 expressions were regulated in HLF cells by overexpression vectors and RNA interference. Cell proliferation and fibrosis-related gene expression were checked by the Cell Counting Kit-8 (CCK-8) assay and western blotting. CircBank’s prediction of the association between miR-155 and circ_0003609 was supported by a dual-luciferase reporter experiment. The function of the miR-155/sirtuin 1 More >

JUNZHE YI^1,#, BINBIN LI^2,#, XIAOMIN YIN³, LINGRUI LIU¹, CAILU SONG¹, YING ZHAO⁴, MANBO CAI³, HAILIN TANG¹, DONG CHEN^4,*, NING LYU^1,*

Oncology Research, Vol.32, No.6, pp. 1129-1139, 2024, DOI:10.32604/or.2024.047524 - 23 May 2024

Abstract Circular RNAs (circRNAs) have been recognized as pivotal regulators in tumorigenesis, yet the biological functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma (HCC) remain elusive. We sought to unveil the expression profile and biological role of circMYBL2 in HCC. Initial microarray analyses were conducted to probe the expression profile of circMYBL2 in HCC cells, and qRT‒PCR analysis was then performed in HCC cell lines and tissues, revealing significant upregulation of circMYBL2. Subsequent experiments were conducted to evaluate the biological function of circMYBL2 in HCC progression. Furthermore, bioinformatics analysis, qRT‒PCR… More >

Ali Shokor Golam^*

Frontiers in Heat and Mass Transfer, Vol.22, No.2, pp. 633-653, 2024, DOI:10.32604/fhmt.2024.050218 - 20 May 2024

Abstract The thermal-hydraulic performance of plain tubes with and without wire coils in turbulent regimes is investigated experimentally and numerically. The effects of wire coil distribution (circular cross section) within the tube were explored experimentally, and water was employed as the working fluid. The numerical simulation was carried out using software programmer ANSYS Fluent 2019 R3 using the finite-volume approach. In the turbulent regime, six cross-sectioned wire coils were analyzed, including: circular, rectangular, hexagonal, square, star shape, and triangle. The utilization of a tube with a wire coil has been shown to increase heat transfer rate More >

Qi Zhang^1,2,4,5, Zhixin Chen³, Yang Wu^4,*, Guoqi Xiang², Guang Wen¹, Xuegang Zhang², Yongchun Xie², Guangchun Yang²

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 593-619, 2024, DOI:10.32604/cmes.2023.046319 - 16 April 2024

Abstract Although there is currently no unified standard theoretical formula for calculating the contact stress of cylindrical gears with a circular arc tooth trace (referred to as CATT gear), a mathematical model for determining the contact stress of CATT gear is essential for studying how parameters affect its contact stress and building the contact stress limit state equation for contact stress reliability analysis. In this study, a mathematical relationship between design parameters and contact stress is formulated using the Kriging Metamodel. To enhance the model’s accuracy, we propose a new hybrid algorithm that merges the genetic… More >

JIA SHAO^1,2, CAN ZHANG², YAONAN TANG², AIQIN HE², WEIPEI ZHU^1,*

BIOCELL, Vol.48, No.4, pp. 571-580, 2024, DOI:10.32604/biocell.2024.049092 - 09 April 2024

Abstract Objective: Previous studies indicated that aberrant circular RNA (circRNA) expression affects gene expression regulatory networks, leading to the aberrant activation of tumor pathways and promoting tumor cell growth. However, the expression, clinical significance, and effects on cell propagation, invasion, and dissemination of circRNA_001896 in cervical cancer (CC) tissues remain unclear. Methods: The Gene Expression Omnibus (GEO) datasets (GSE113696 and GSE102686) were used to examine differential circRNA expression in CC and adjacent tissues. The expression of circRNA_001896 was detected in 72 CC patients using fluorescence quantitative PCR. Correlation analysis with clinical pathological features was performed through… More >