Yandong Lu*1, Fangguo Li*1, Tao Xu†, Jie Sun*1
Oncology Research, Vol.23, No.4, pp. 155-163, 2015, DOI:10.3727/096504016X14519157902681
Abstract Chondrosarcoma (CHS) is the second most common malignant bone sarcoma with increased risk of invasion
and metastasis. However, the regulatory mechanisms of CHS tumorigenesis remain unknown. Here we investigated the novel role of miR-497 in regulating chondrosarcoma cell growth and cell cycle arrest. RT-PCR analysis showed that the expression of miR-497 is aberrantly downregulated in human chondrosarcoma samples
and cells. After transfection with miR-497 mimic or antagomir, the proliferation and apoptosis of JJ012 and
OUMS-27 chondrosarcoma cells were determined by CCK-8 assay and flow cytometric analysis, respectively.
Results showed that the proliferation capacity of JJ012… More >
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