WEIGANG XIU^1,#, XINGYU LIU^1,2,#, KAIXIN HU^1,2, QIN ZHANG^3,*, HUASHAN SHI^4,*

Oncology Research, Vol.32, No.10, pp. 1613-1621, 2024, DOI:10.32604/or.2024.047933

Abstract Elevated serum cholesterol metabolism is associated with a reduced risk of lung cancer. Disrupted cholesterol metabolism is evident in both lung cancer patients and tumor cells. Inhibiting tumor cell cholesterol uptake or biosynthesis pathways, through the modulation of receptors and enzymes such as liver X receptor and sterol-regulatory element binding protein 2, effectively restrains lung tumor growth. Similarly, promoting cholesterol excretion yields comparable effects. Cholesterol metabolites, including oxysterols and isoprenoids, play a crucial role in regulating cholesterol metabolism within tumor cells, consequently impacting cancer progression. In lung cancer patients, both the cholesterol levels in the… More >

TIANXIANG ZHANG^1,#, MEISHAN ZHANG^1,#, MINGHUI SHI^1,#, WEIJIANG JIN^1,#, SHUMIAO ZHANG^2,#, MENGYUAN FAN³, YIMENG LI¹, YUPING MENG², XUELIN TIAN⁴, SHUQIANG LIU^1,*, DEFU HU^1,*

BIOCELL, Vol.45, No.2, pp. 281-306, 2021, DOI:10.32604/biocell.2021.010277

Abstract Male muskrats (Ondatra zibethicus L.) secrete musk from their scent glands during musk secretion season. Musk plays an important role as a communication pheromone during the breeding season. In this study, gas chromatography–mass spectrometry (GC–MS) was used to analyze the main components of musk. The GC–MS results after methyl esterification showed that 71.55% of the musk is composed of fatty acids. The other components of muskrat musk include cholesterol (9.31%) and other organics. Transcriptome comparison between musk secretion and non-secretion seasons showed significant changes in the scent glands for 53 genes involved in fatty acid and More >