MEIR DJALDETTI^*

Oncology Research, Vol.32, No.9, pp. 1389-1399, 2024, DOI:10.32604/or.2024.049745 - 23 August 2024

Abstract Resveratrol (RSV), the primary polyphenol found in grapes, has been revealed to have anti-inflammatory properties by reducing the capacity of the peripheral blood mononuclear cells to produce pro-inflammatory cytokines, including IL-1β, IL-6, IL-1ra and TNFα. Considering the close association between chronic inflammation and cancer development, RSV’s immunomodulatory properties are one way by which the polyphenol may inhibit cancer initiation, proliferation, neovascularization, and migration. Resveratrol influences the generation of microtumor environment which is one of the key factors in cancer progress. In addition to immunomodulation, RSV inhibits cancer development by expressing anti-oxidant effects, causing cell cycle… More > Graphic Abstract

David E. Dawe^1,2, Salaheddin Mahmud^3,4

Canadian Journal of Urology, Vol.24, No.6, pp. 9081-9088, 2017

Abstract Introduction: During their lives, 1 in 8 men will be diagnosed with prostate cancer. Several drugs have been shown to decrease prostate cancer risk, but have not been widely used in prostate cancer prevention because of concerns about side-effects and cost-effectiveness. Statins are indicated for prevention of cardiovascular disease, have an excellent benefit to risk profile, and some studies suggest that statins may reduce the risk of prostate cancer.
Materials and methods: We performed a systematic search of Medline (Ovid), EMBASE (Ovid), and PubMed. This search informed a narrative review of the biological rationale for why statins… More >

Leonard G. Gomella

Canadian Journal of Urology, Vol.17, No.3, pp. 5148-5148, 2010

Abstract This article has no abstract. More >

Neil Fleshner, Rami Al Azab

Canadian Journal of Urology, Vol.12, Suppl.3, pp. 2-4, 2005

Abstract Introduction: If an agent can slow the growth of existing prostate cancer cells, it remains plausible that it may be effective as an adjunct to surgery, radiation or chemotherapy.
Discussion: Level-1 evidence will be needed in order to definitively prove the efficacy of agents as chemoprevention strategies for prostate cancer. Currently, only finasteride fulfills this criterion. Two major trials are underway that will assess the role of soy, vitamin E and selenium in prostate cancer prevention.
Conclusion: Tantalizing prospects for effective of prostate cancer exist. Fortunately, well-conducted randomized trials will allow us to answer many of these questions More >