JULING FENG1,3, HAODONG CHEN1, YANGBO LIU1, QIDI AI1, YANTAO YANG1, LEI ZHAO4, SHIFENG CHU2,#,*, NAIHONG CHEN1,2,#,*
BIOCELL, Vol.48, No.6, pp. 981-990, 2024, DOI:10.32604/biocell.2024.050011
- 10 June 2024
Abstract Introduction: Chemokine-like factor 1 (CKLF1) is a chemokine that is overexpressed in several diseases. Our previous findings revealed a significant increase in CKLF1 expression in the ischemic brain, suggesting its potential as a therapeutic target for ischemic stroke. Methods: In this study, we examined the expression dynamics of CKLF1 in both in vivo and in vitro models of ischemic cardiac injury. Myocardial infarction (MI) was induced in vivo by ligation of the left anterior descending artery (LAD) of the rat heart. The levels of CKLF1, Creatine Kinase MB Isoenzyme (CK-MB), and Lactate dehydrogenase (LDH) in the serum were… More >
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