Feng Shuai*, Bo Wang†, Shuxiao Dong‡
Oncology Research, Vol.26, No.8, pp. 1295-1305, 2018, DOI:10.3727/096504018X15172747209020
Abstract Among all of the miRNAs, miR-204 has gained considerable attention in the field of cancer research. This
study aimed to reveal the detailed functions and the underlying mechanism of miR-204 in colorectal cancer
(CRC) cells. The expressions of miR-204 in CRC tumor tissues and cell lines were monitored. Expressions
of miR-204 and CXCL8 in Caco-2 and HT-29 cells were altered by transfection, and then cell viability, apoptosis, migration, invasion, EMT-related protein expression, and PI3K/AKT/mTOR pathway protein expression were assessed. We found that miR-204 was expressed at low levels in CRC tumor tissues and cell lines… More >
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