POOJA JAISWAL1, VERSHA TRIPATHI1, ANSHUL ASSAIYA2, DHARMENDRA KASHYAP3, RAHUL DUBEY4, ANAMIKA SINGH4, JANESH KUMAR2, HEM CHANDRA JHA3, RAJESH SHARMA5, AMIT KUMAR DIXIT6, HAMENDRA SINGH PARMAR1,*
BIOCELL, Vol.46, No.12, pp. 2645-2657, 2022, DOI:10.32604/biocell.2022.021754
- 10 August 2022
Abstract Triple-negative breast cancer (TNBC) cell line MDA-MB-231 is known for Warburg metabolism and defects in mitochondria. On the other hand, dipeptidyl peptidase-IV (DPP-IV) inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis, but no study has evaluated the influence of these drugs on mitochondrial biogenesis on metastatic breast cancer cell line. We have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase (AMPK), which activates the downstream transcription factors PGC-1α, PGC-1β, or FOXO1 for mitochondrial biogenesis; above-mentioned incretin-based… More >
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