Zhongyuan Yin*, Lin Yang†, Feng Wu‡, Jinshuo Fan‡, Juanjuan Xu‡, Yang Jin‡, Guanghai Yang§
Oncology Research, Vol.27, No.9, pp. 1069-1077, 2019, DOI:10.3727/096504019X15566157027506
Abstract Cysteine oxidation occurs at the active site of deubiquitinases (DUBs) during many biologic signaling cascades. Here we report that hepatocellular carcinoma cells (HCCs) generated higher levels of endogenous
reactive oxygen species (ROS). This elevated ROS production was inhibited by NADPH oxidase inhibitor
diphenylene iodonium (DPI) and mitochondria electron chain inhibitor rotenone in HCC cells. Moreover, we
found that H2O2 could activate NF- B-dependent inflammatory effect through increased induction of matrix
metalloproteinase 2 (MMP2), MMP9, and intercellular adhesion molecule 1 (ICAM1) expression levels. In
addition, we found that H2O2 could prolong NF- B activation by suppressing the More >
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