Xiaobin Hou*1, Tinghui Li†1, Zhipeng Ren*, Yang Liu*
Oncology Research, Vol.24, No.4, pp. 247-253, 2016, DOI:10.3727/096504016X14652175055765
Abstract Mutation of breast cancer 2, early onset (BRCA2) has been identified as a vital risk factor for esophageal cancer
(EC). To date, several proteins have been reported as BRCA2-interacting proteins and are associated with multiple biological processes. This study's aim was to identify a novel interactive protein of BRCA2 and to explore
its functional roles in EC. A yeast two-hybrid screening was performed to identify a novel BRCA2-interacting
protein. Glutathione-S-transferase (GST) pull-down analysis was performed to find out how the binding domain
of BRCA2 interacts with LIM domains containing 1 (LIMD1). The interaction between LIMD1… More >
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