AUGUSTO FUSCO1, STEFANO BONOMI2,*, LUCA PADUA1,2
BIOCELL, Vol.49, No.1, pp. 1-5, 2025, DOI:10.32604/biocell.2024.058418
- 24 January 2025
Abstract
Connective tissue is a dynamic structure that reacts to environmental cues to maintain homeostasis, including mechanical properties. Mechanical load influences extracellular matrix (ECM)—cell interactions and modulates cellular behavior. Mechano-regulation processes involve matrix modification and cell activation to preserve tissue function. The ECM remodeling is crucial for force transmission. Cytoskeleton components are involved in force sensing and transmission, affecting cellular adhesion, motility, and gene expression. Proper mechanical loading helps to maintain tissue health, while imbalances may lead to pathological processes. Active and passive movement, including manual mobilization, improves connective tissue elasticity, promotes ECM-cell homeostasis, and More >
Graphic Abstract
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