JIAJUN HUANG^1,#, WEI WANG^1,#, WENTONG LIN², HENGSEN CAI³, ZHIHAN ZHU¹, WAQAS AHMED⁴, QIANKUN ZHANG¹, JIALE LIU¹, YIFAN ZHANG¹, RONG LI¹, ZHINUO LI¹, AHSAN ALI KHAN⁵, DENG LU³, YONG HU⁶, LUKUI CHEN^1,*

BIOCELL, Vol.48, No.10, pp. 1405-1418, 2024, DOI:10.32604/biocell.2024.053148 - 02 October 2024

Abstract Degeneration and death of nerve cells are inevitable with the occurrence and progression of nervous system disorders. Researchers transplanted neural stem cells into relevant areas, trying to solve the difficulty of neural cell loss by differentiating neural stem cells into various nerve cells. In recent years, however, studies have shown that transplanted neural stem cells help neural tissues regenerate and return to normal through paracrine action rather than just replacing cells. Exosomes are essential paracrine mediators, which can participate in cell communication through substance transmission. In this regard, this review mainly discusses the current research More >

YASHVI SHARMA¹, SHARDA RAY², SUJATA MOHANTY^1,*

BIOCELL, Vol.46, No.6, pp. 1435-1438, 2022, DOI:10.32604/biocell.2022.018612 - 07 February 2022

Abstract Neurodegenerative disorders are a vicious woe to the public health and wellness. Uncertainty in their underlying causes, lack of effective biomarkers for their early detection, existence of only supportive therapy, and their ever rising incidence creates an unmatched need for targeted therapies. Mesenchymal Stem Cells (MSCs) have found to be promising candidates for regenerative and remedial therapy in neurodegenerative disorders, however several biological risks and practical issues impede in their translational utility. Deriving from MSCs are certain Extracellular Vesicles (EVs), which aid in the paracrine action of MSCs and have lately gained the scientific interest More >

DICKSON KOFI WIREDU OCANSEY^1,2,*, XINWEI XU¹, LU ZHANG¹, FEI MAO^1,*

BIOCELL, Vol.46, No.5, pp. 1169-1172, 2022, DOI:10.32604/biocell.2022.018470 - 06 January 2022

Abstract Stem cell research is a promising area of transplantation and regenerative medicine with tremendous potential for improving the clinical treatment and diagnostic options across a variety of conditions and enhancing understanding of human development. Over the past few decades, mesenchymal stem cell (MSCs) studies have exponentially increased with a promising outcome. However, regardless of the huge investment and the research attention given to stem cell research, FDA approval for clinical use is still lacking. Amid the challenges confronting stem cell research as a cell-based product, there appears to be evidence of superior effect and heightened… More >

YASHVI SHARMA, SUCHI GUPTA, SUJATA MOHANTY^*

BIOCELL, Vol.45, No.3, pp. 517-520, 2021, DOI:10.32604/biocell.2021.014621 - 03 March 2021

Abstract In these times of despair when a nano-sized organism, the SARS-CoV-2, has rendered the human race helpless, made the global health status decline, and drowned the world economy, a ray of hope comes from another nano-sized particle, the exosome. The potential of mesenchymal stem cells has already been established in COVID-19; however, cell-based therapy has its risks. We thereby propose cell-free therapy using stem cells-derived exosomes to fight against COVID-19, as they can be a game-changer owing to their immunomodulatory nature, which combats the cytokine storm characterizing this disease, and their practical efficiency, which will More >