Bahareh Tajvidi Safa¹, Jordan Rosenbohm¹, Ruiguo Yang^1,2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.011477

Abstract Cell-cell adhesions are often subjected to mechanical strains of different rates and magnitudes in normal tissue function and in disease conditions. To date, few strategies exist to directly and quantitatively investigate the effect of mechanical forces exerted by cell-cell adhesions, even less the effect of applied load on the transduction of these forces into biochemical signals. To address this knowledge gap, we designed and fabricated a platform that performs quantitative mechanical characterization of single cell-cell adhesion structures using two photon polymerization of multiple materials [1]. This microsystem provides interrogation and stimulation of cell-cell junctions through… More >

IVANA PAJIC-LIJAKOVIC^*, MILAN MILIVOJEVIC

BIOCELL, Vol.47, No.1, pp. 15-25, 2023, DOI:10.32604/biocell.2023.023469 - 26 September 2022

Abstract A key feature that distinguishes cancer cells from all other cells is their capability to spread throughout the body. Although how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been comprehensively formulated, the impact of physical interactions on cell spreading remains less understood. Cumulative effects of physical interactions exist as the interplay between various physical parameters such as (1) tissue surface tension, (2) viscoelasticity caused by collective cell migration, and (3) solid stress accumulated in the cell aggregate core region. This review aims to point out… More >

S.R.K. Vedula¹, T.S. Lim², P.J. Kausalya³, W. Hunziker³, G. Rajagopal², C.T. Lim^1,4

Molecular & Cellular Biomechanics, Vol.2, No.3, pp. 105-124, 2005, DOI:10.3970/mcb.2005.002.105

Abstract Cell-cell adhesion is an extremely important phenomenon as it influences several biologically important processes such as inflammation, cell migration, proliferation, differentiation and even cancer metastasis. Furthermore, proteins involved in cell-cell adhesion are also important from the perspective of facilitating better drug delivery across epithelia. The adhesion forces imparted by proteins involved in cell-cell adhesion have been the focus of research for sometime. However, with the advent of nanotechnological techniques such as the atomic force microscopy (AFM), we can now quantitatively probe these adhesion forces not only at the cellular but also molecular level. Here, we More >