Harmonie Perdreau1,2, Erwan Mortier1,2, Grégory Bouchaud1,2, Véronique Solé1,2, Yvan Boublik3, Ariane Plet1,2,*, Yannick Jacques1,2,*
European Cytokine Network, Vol.21, No.4, pp. 297-307, 2010, DOI:10.1684/ecn.2010.0207
Abstract Interleukin (IL)-15 is a cytokine critical for the homeostasis and the function of NK cells, NK-Tcells, and memory CD8+ T cells. IL-15 signals are delivered through the IL-15Rβ and the commonγ (γc) receptorchains. The third receptor chain, IL-15Rα, confers specificity and high affinity for the cytokine. While IL-15 canactivate with high affinity the trimeric receptor expressed by a target cell (cis-presentation), IL-15Rα is alsoknown to trans-present IL-15 with high affinity to target cells expressing the IL-15Rβ/γc complex. In order tocompare the IL-15 cis- and trans-presentation processes, and using a T cell line expressing both IL-15Rα/β/γc andIL-15Rβ/γc, we analyzed cell… More >
Login
Register
