Lixia Jiang*1, Shaohua Shi†1, Qiaofa Shi‡, Huijuan Zhang*, Yu Xia§, Tianyu Zhong*
Oncology Research, Vol.26, No.7, pp. 1055-1062, 2018, DOI:10.3727/096504018X15152056890500
Abstract HIF-2α knockdown inhibits proliferation, arrests the cell cycle, and promotes apoptosis and autophagy under
hypoxic conditions in cervical cancer. However, the upstream regulatory mechanism of HIF-2α expression is
unclear. MicroRNAs (miRNAs) degrade target mRNAs by binding to the 3'-untranslated region of mRNAs. In
this study, we investigated the role of miRNAs in the regulation of HIF-2α expression in cervical cancer under
hypoxic conditions. miRNAs regulating HIF-2α expression were predicted using TargetScan and miRanda
and were determined in cervical cancer under hypoxic conditions by qRT-PCR. Additionally, the targeted
regulation of HIF-2α by miR-519d-3p was evaluated by… More >
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