Huiyan Liang1, Wei Fang1, Xiqiao Feng1,*
The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012719
Abstract Cell–extracellular matrix (ECM) interactions play a pivotal role in many functions of cells, for example, sensing, signaling, migration, and gene expression. The spatial-temporal dynamic evolution of cell–substrate adhesions involves complicated mechano-bio-chemical coupling mechanisms of integrin, adaptor and signaling proteins, and the interplay between the cytoskeleton and ECM as well. In this paper, we establish a multiscale dynamic model of cell–substrate interfaces considering intermolecular force transmission pathways, i.e., intra- and extra-cellular bond dynamics, and mechanochemical coupling regulations. To illustrate its applications, this model is used to reproduce several adhesion-related experimental phenomena of cells, including substrate rigidity… More >
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