Luyong Xu, Jie Li, Zheng Kuang, Yan Kuang, Hong Wu
Oncology Research, Vol.26, No.4, pp. 617-624, 2018, DOI:10.3727/096504017X15043589260618
Abstract Grb2-associated binder 1 (Gab1) is often aberrant in cancerous cells and tissues, whose alteration is responsible
for aggressive phenotypes. In this study, we examined the Gab1 expression in human oral squamous cell carcinoma (OSCC) tissues and investigated the cellular and molecular effect of Gab1 on migration, invasion, and
cell growth of the OSCC cell lines SCC15 and SCC25. We found that Gab1 was overexpressed in OSCC tissues and cells, which is related to the protein levels of various molecules associated with cellular proliferation,
migration, and invasion. Functional assays identified that Gab1 overexpression promoted cell proliferation… More >
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