JUAN C. STOCKERT1,2,*, SILVINA A. ROMERO1, MARCELO N. FELIX-POZZI3, ALFONSO BLÁZQUEZ-CASTRO4
BIOCELL, Vol.47, No.4, pp. 919-928, 2023, DOI:10.32604/biocell.2023.026631
Abstract
The 10boron neutron-capture therapy (BNCT) is an emerging antitumoral method that shows increasing biomedical interest. BNCT is based on the selective accumulation of the 10boron isotope within the tumor, which is then irradiated with low-energy thermal neutrons, generating nuclear fission that produces 7lithium, 4helium, and γ rays. Simple catechol-borate esters have been rather overlooked as precursors of melanin biosynthesis, and therefore, a proof-of-concept approach for using dopamine-borate (DABO) as a suitable boron-containing candidate for potential BNCT is presented here. DABO can spontaneously oxidize and autopolymerize in vitro, giving a soluble, eumelanin-like brown-black poly-DABO product. Melanotic melanoma cell cultures treated with… More >
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