Hongde Li^*†‡, Yueshuo Li^*†‡, Jianmin Hu^*†‡, Sufang Liu^§, Xiangjian Luo^*†‡¶, Min Tang^*†‡, Ann M. Bode^#, Zigang Dong^#**, Xinqi Liu^††, Weihua Liao^‡‡, Ya Cao^{*†‡¶ §§¶¶}

Oncology Research, Vol.28, No.7-8, pp. 763-778, 2020, DOI:10.3727/096504021X16135618512563

Abstract Epstein–Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) plays an important oncogenic role in the viral latent infection. Recently, increasing evidence indicates that the high expression of LMP1 during EBV lytic cycle is related to the viral lytic replication. However, the mechanism by which LMP1 regulates EBV lytic replication remains unclear. (−)-Epigallocatechin-3-gallate (EGCG) prevents carcinogenesis by directly targeting numerous membrane proteins and effectively inhibits EBV lytic cascade. Here, we demonstrated that LMP1 promotes EBV lytic replication through the downstream signal molecules MAPKs, including ERKs, p38, and JNKs. LMP1 induces the phosphorylation of p53 through MAPKs to enhance the ability of… More >

Wissem Sahmim, Georges Eid, Febrina Dellarose Boer, Hubert Chapuis, Philippe Gérardin, Christine Gérardin-Charbonnier^*

Journal of Renewable Materials, Vol.10, No.6, pp. 1491-1503, 2022, DOI:10.32604/jrm.2022.016364

Abstract This study evaluated the methods of grafting commercial catechin with fatty acids, namely capric acid (C10), lauric acid (C12), and myristic acid (C14) through esterification. Specimens of beech wood (Fagus sylvatica L.) were impregnated with catechin and modified catechin-fatty acids, separately, at a 5% concentration diluted in ethanol using vacuum pressure treatment and subjected to leaching. The weight percentage gain before leaching (WPG), after leaching (WPGAL), and weight loss due to leaching (PL) were investigated. Both leached and unleached samples were tested against white-rot fungi (Trametes versicolor) in Petri-dishes for twelve weeks. Results show that samples treated with modified catechin-fatty… More > Graphic Abstract

Wissem Sahmim¹, Febrina Dellarose Boer¹, Hubert Chapuis¹, Firmin Obounou-Akong¹, Antonio Pizzi², Philippe Gérardin¹, Christine Gérardin-Charbonnier^1,*

Journal of Renewable Materials, Vol.10, No.5, pp. 1175-1184, 2022, DOI:10.32604/jrm.2022.016365

Abstract With the current trend of increasing efforts to develop non-isocyanate-based polyurethanes (NIPUs), this study aimed to check the feasibility of the development of a method using cyclic carbonate modified catechin and amine to synthesis non-isocyanate urethane with the objective to further extend these results to polyurethane synthesis. The methods used in this study consist of four steps: glycidilation of catechin, hydrolysis of epoxide, cyclic carbonate synthesis, and carbamate synthesis through condensation of butylamine. The resulting products were analyzed using FTIR (Fourier transform infrared) spectroscopy and NMR (nuclear magnetic resonance) spectroscopy. The results showed that carbamate could be successfully obtained through… More > Graphic Abstract