Zhenfeng Jiang*1, Lifen Yao†1, Hongge Ma†, Panpan Xu†, Zhiyan Li†, Mian Guo‡, Jianhang Chen*, Hongbo Bao§, Shupei Qiao¶, Yufang Zhao¶, Jia Shen#, Minwei Zhu*, Carolyn Meyers**, Guizhen Ma††,
Chuncheng Xie*, Li Liu*, Haiyang Wang*, Wang Zhang*, Qi Dong†, Hong Shen*, Zhiguo Lin*
Oncology Research, Vol.25, No.6, pp. 1009-1019, 2017, DOI:10.3727/096504016X14813859905646
Abstract Pyroptosis is a type of proinflammatory programmed cell death mediated by caspase 1 activity and occurs in
several types of eukaryotic tumor cells, including gliomas. MicroRNAs (miRNAs), small endogenous noncoding RNAs, have been demonstrated to be advantageous in glioma therapy. However, the question of whether
miRNAs regulate pyroptosis in glioma remains unknown. The current study found that caspase 1 expression was substantially increased in both glioma tissues and glioma cell lines, U87 and T98G, while miR-214
expression was significantly downregulated. Luciferase reporter assay recognized caspase 1 as a target gene of
miR-214. These findings demonstrate More >
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