MINGZHAO LI¹, QIAN ZHANG², WENBIN HUANG¹, SHIYING ZHANG¹, NAN JIANG², XIAOSHUAI HUANG^3,*, FENG CHEN^2,*

BIOCELL, Vol.47, No.1, pp. 205-214, 2023, DOI:10.32604/biocell.2022.022572 - 26 September 2022

Abstract Cancer progression involves the sonic hedgehog (SHH) pathway, in which the receptor PTCH1 actives the downstream pathways. Dysfunction of PTCH1 can lead to nevoid basal cell carcinoma Syndrome (NBCCs) including neoplastic disease and congenital disorder. To evaluate the relationship between PTCH1 and cancer, we applied the CRISPR/Cas9 system to knock out PTCH1 in oral nontumorous epithelial cells (GMSM-K). Then we screened six PTCH1 variants associated with cleft lip/palate (CL/P), one of the congenital disorders in NBCCs, and generated PTCH1 variant and wild-type recombinant PTCH1^−/− GMSM-K cell lines. Transcriptome sequencing was conducted in these cell lines. The… More >

A. Sheryl Oliver¹, T. Jayasankar², K. R. Sekar^3,*, T. Kalavathi Devi⁴, R. Shalini⁵, S. Poojalaxmi⁵, N. G. Viswesh⁵

Intelligent Automation & Soft Computing, Vol.30, No.3, pp. 755-770, 2021, DOI:10.32604/iasc.2021.016242 - 20 August 2021

Abstract Lung cancer is a poorly understood disease. Smokers may develop lung cancer due to the inhalation of carcinogenic substances while smoking, but non-smokers may develop this disease as well. Lung cancer can spread to other parts of the body and this process is called metastasis. Because the lung cancer is difficult to identify in the initial stages. The objective of this work is to reduce the mortality rate of the disease by identifying it at an earlier stage based on the existing symptoms. Artificial intelligence plays active roles in tasks such as entropy extraction through… More >

JIA-FONG HONG¹, BAGHDAD OUDDANE², JIANG-SHIOU HWANG^3,4,5, HANS-UWE DAHMS^1,6,7,*

BIOCELL, Vol.45, No.1, pp. 65-77, 2021, DOI:10.32604/biocell.2021.014154 - 26 January 2021

Abstract Harmful algal blooms (HABs) that are formed by cyanobacteria have become a serious issue worldwide in recent years. Cyanobacteria can release a type of secondary metabolites called cyanotoxins into aquatic systems which may indirectly or directly provide health risks to the environment and humans. Cyanotoxins provide some of the most powerful natural poisons including potent neurotoxins, hepatotoxins, cytotoxins, and endotoxins that may result in environmental health risks, and long-term morbidity and mortality to animals and humans. In this research, we used the chemcomputational tool Molinspiration for molecular property predictions, Pred-hERG 4.2 web software for cardiac… More >

Qiaodong Xu¹, Songgang Gu¹, Jiahong Liang, Zhihua Lin, Shaodong Zheng, Jiang Yan

Oncology Research, Vol.27, No.4, pp. 509-514, 2019, DOI:10.3727/096504018X15278771272963

Abstract Hepatocellular carcinoma (HCC) is one of the major malignant tumors that lead to death. Chronic hepatitis B virus infection is an important risk factor for HCC initiation. HBx protein, encoded by the HBV X gene, is a significant factor that promotes HBV-related HCC, although the exact molecular mechanism remains unclear. This article summarizes the pathological roles and related mechanisms of HBx in HCC. HBx plays a carcinogenic role by promoting cell proliferation, metastasis, and angiogenesis and inhibiting apoptosis in HCC. A detailed study of the biological functions of HBx will help to elucidate the mechanism More >