Yingchao Li*, Xiaoni Yan*, Li Ren*, Yang Li†
Oncology Research, Vol.26, No.1, pp. 1-8, 2018, DOI:10.3727/096504016X14772410356982
Abstract Epithelial–mesenchymal transition (EMT) is one of the most important mechanisms in the metastasis of various cancers, including gastric cancer (GC). In this study, we explored the putative significance of miR-644a
and its role in EMT-mediated metastasis of GC. We first detected the expression of miR-644a in a cohort of
107 GC tissues using quantitative RT-PCR. The expression of miR-644a was suppressed in GC tissues and was
associated with a later clinical stage and tumor metastasis. Restoring the expression of miR-644a could significantly suppress the migration and invasion of HGC-27 and SGC-7901 cells, which might be More >
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