SAIDA MELIANI1, SOUMAYA TOUMI1, HEYTHEM DJAHOUDI2, KHALED DEGHDEGH3, KAMEL AMOURA4, ABDELGHANI DJAHOUDI5,*
BIOCELL, Vol.44, No.2, pp. 175-182, 2020, DOI:10.32604/biocell.2020.09097
Abstract Objective: The aim of this study is to detect in vitro the synergetic activity of colistin in combination with
imipenem, amikacin or ciprofloxacin, at sub-inhibitory concentrations, against carbapenems-resistant (CR) Acinetobacter
baumannii and Pseudomonas aeruginosa strains isolated from various wards in Annaba teaching hospital in eastern Algeria.
Materials and Methods: The minimal inhibitory concentrations (MIC) were determined by broth macrodilution (BMD).
Carbapenemase encoding genes were screened using polymerase chain reaction (PCR). The activity of colistin in
combination with second antibiotic was evaluated by the Checkerboard Technique.
Results: 39 CR P. aeruginosa and 21 CR A. baumanni strains where collected. The MIC values ranging… More >
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