FEI CHU¹, KAI TONG¹, XIANG GU¹, MEI BAO¹, YANFEN CHEN¹, BIN WANG², YANHUA SHAO¹, LING WEI^1,*

Oncology Research, Vol.32, No.10, pp. 1661-1671, 2024, DOI:10.32604/or.2024.048287

Abstract Glutamine is one of the most abundant non-essential amino acids in human plasma and plays a crucial role in many biological processes of the human body. Tumor cells take up a large amount of glutamine to meet their rapid proliferation requirements, which is supported by the upregulation of glutamine transporters. Targeted inhibition of glutamine transporters effectively inhibits cell growth and proliferation in tumors. Among all cancers, digestive system malignant tumors (DSMTs) have the highest incidence and mortality rates, and the current therapeutic strategies for DSMTs are mainly surgical resection and chemotherapy. Due to the relatively More > Graphic Abstract

YI LI¹, TIANYI WANG¹, HAORAN DING¹, SHIYONG ZHUANG¹, XIAOBO DAI¹, BING YAN^1,2,*

Oncology Research, Vol.32, No.10, pp. 1623-1635, 2024, DOI:10.32604/or.2024.048191

Abstract Background: Oral cancer, a malignancy that is prevalent worldwide, is often diagnosed at an advanced stage. MicroRNAs (miRNAs) in circulating exosomes have emerged as promising cancer biomarkers. The role of miRNA let-7c-5p in oral cancer remains underexplored, and its potential involvement in tumorigenesis warrants comprehensive investigation. Methods: Serum samples from 30 patients with oral cancer and 20 healthy controls were used to isolate exosomes and quantify their RNA content. Isolation of the exosomes was confirmed through transmission electron microscopy. Quantitative PCR was used to assess the miRNA profiles. The effects of let-7c-5p and TAGLN overexpression… More >

WEIGANG XIU^1,#, XINGYU LIU^1,2,#, KAIXIN HU^1,2, QIN ZHANG^3,*, HUASHAN SHI^4,*

Oncology Research, Vol.32, No.10, pp. 1613-1621, 2024, DOI:10.32604/or.2024.047933

Abstract Elevated serum cholesterol metabolism is associated with a reduced risk of lung cancer. Disrupted cholesterol metabolism is evident in both lung cancer patients and tumor cells. Inhibiting tumor cell cholesterol uptake or biosynthesis pathways, through the modulation of receptors and enzymes such as liver X receptor and sterol-regulatory element binding protein 2, effectively restrains lung tumor growth. Similarly, promoting cholesterol excretion yields comparable effects. Cholesterol metabolites, including oxysterols and isoprenoids, play a crucial role in regulating cholesterol metabolism within tumor cells, consequently impacting cancer progression. In lung cancer patients, both the cholesterol levels in the… More >

SHUBHRA CHANDRA^1,2, JENNIFER C. WILSON^1,2, DAVID GOOD³, MING Q. WEI^1,2,*

Oncology Research, Vol.32, No.10, pp. 1543-1564, 2024, DOI:10.32604/or.2024.043987

Abstract The advent of RNA therapy, particularly through the development of mRNA cancer vaccines, has ushered in a new era in the field of oncology. This article provides a concise overview of the key principles, recent advancements, and potential implications of mRNA cancer vaccines as a groundbreaking modality in cancer treatment. mRNA cancer vaccines represent a revolutionary approach to combatting cancer by leveraging the body’s innate immune system. These vaccines are designed to deliver specific mRNA sequences encoding cancer-associated antigens, prompting the immune system to recognize and mount a targeted response against malignant cells. This personalized… More > Graphic Abstract

YUN WANG¹, XIAOJIANG LI², DALONG LIU², ZHIFENG WANG³, JICHEN XIA⁴, LIJUN WANG⁵, XUDONG ZHANG^6,*

Oncology Research, Vol.32, No.10, pp. 1649-1660, 2024, DOI:10.32604/or.2024.043482

Abstract Exosomes, minute vesicles ubiquitously released by diverse cell types, serve as critical mediators in intercellular communication. Their pathophysiological relevance, especially in malignancies, has garnered significant attention. A meticulous exploration of the exosomal impact on cancer development has unveiled avenues for innovative and clinically valuable techniques. The cargo conveyed by exosomes exerts transformative effects on both local and distant microenvironments, thereby influencing a broad spectrum of biological responses in recipient cells. These membrane-bound extracellular vesicles (EVs) play a pivotal role in delivering bioactive molecules among cells and organs. Cellular and biological processes in recipient cells, ranging… More > Graphic Abstract

Youqi Jiang^1,#, Bing Wu^2,#, Jiahui Chen³, Ruyi Jin³, Guangshan Jin³, Minhao Zhang⁴, Qin Zhou^4,*, Aiji Jiang^2,*

Psycho-Oncologie, Vol.18, No.3, pp. 191-200, 2024, DOI:10.32604/po.2024.053942

Abstract Objective: This study evaluated the effect of resilience on depression among patients with breast cancer from individual and familial perspectives by exploring the mediating and moderating effects of family resilience between individual resilience and depression. Methods: A questionnaire survey was conducted among 337 patients with breast cancer who were admitted to the Oncology Department of Jiangsu Province Hospital. The survey included demographic information, the Connor–Davidson Resilience Scale (CD-RISC), the Family Resilience Assessment Scale (FRAS), and the Chinese version of the Patient Health Questionnaire-9 (PHQ-9) for Depression. The relationship among individual resilience, family resilience, and depression… More >

Huimin Zheng, Minghui Wang^*, Miao Ye

Psycho-Oncologie, Vol.18, No.3, pp. 169-179, 2024, DOI:10.32604/po.2024.052703

Abstract Background: Although fear of cancer recurrence (FCR) is the most important factor affecting the life quality of young breast cancer patients, and it may be affected by the patient’s personality, marital relationship and communication, there is a lack of research on the relationship between adult attachment, self-disclosure and FCR in patients. This study investigated the current situation of FCR in young breast cancer patients, its correlation with adult attachment and self-disclosure and its influencing factors, in order to predict the impact of adult attachment and self-disclosure of patients to spouse on FCR. Methods: A survey… More >

Nevena Stojadinović¹, Goran Mihajlović¹, Marko Spasić¹, Milena Mladenović¹, Darko Hinić^2,*

Psycho-Oncologie, Vol.18, No.3, pp. 159-168, 2024, DOI:10.32604/po.2024.050122

Abstract Breast cancer is considered one of the most frequent causes of morbidity and death in women. Individuals’ response to information regarding health threats and illness can influence the adjustment of the treatment to existing conditions including the issues of non-completion of treatment or non-attendance at medical appointments. The study aimed to examine the relationship between illness perception, body image dissatisfaction and (mal)adaptive coping styles in breast cancer patients. A sample of 197 patients with diagnosed breast cancer hospitalized at the Center for Oncology and Radiology, Kragujevac, Serbia, was surveyed. The instruments included sociodemographic questionnaire, a… More >

Nada Charfi^1,3,*, Nour Regaieg^1,3, Ines Ayadi^2,3, Najeh Smaoui^1,3, Rim Feki^1,3, Imen Gassara^1,3, Sana Omri^1,3, Lobna Zouari^1,3, Jihène Ben Thabet^1,3, Manel Maâlej Bouali^1,3, Afef Khanfir^2,3, Mohamed Maâlej^1,3

Psycho-Oncologie, Vol.18, No.3, pp. 241-248, 2024, DOI:10.32604/po.2024.049038

Abstract Le diagnostic et la prise en charge du cancer du sein (CS) affectent d’une manière complexe la vie sexuelle des femmes et touchent au symbole de la féminité, qui est très important dans la constitution de l’image du corps. Nos objectifs ont été d’évaluer le fonctionnement sexuel et l’image du corps des patientes en rémission d’un CS localisé, de déterminer les liens entre ces deux paramètres et d’étudier leur rapport avec les modalités thérapeutiques du CS. Nous avons mené une étude transversale, descriptive et analytique au sein des services d’oncologie médicale et de radiothérapie du… More >

Xia Sun^1,#, Qin Li^1,#, Yang Li², Wenjun Yan³, Shuai Gong¹, Wenjing Yan^2,*

Psycho-Oncologie, Vol.18, No.3, pp. 233-240, 2024, DOI:10.32604/po.2024.048087

Abstract Colorectal cancer (CRC) poses significant physical and psychological challenges that necessitate an exploration of factors influencing post-traumatic growth (PTG) for patient well-being. This study aims to investigate the effects of positive psychological capital (PsyCap) and perceived stress on mediating the social support-PTG relation among 673 CRC patients. Social support, positive PsyCap, perceived stress, and PTG were assessed through questionnaires. The results indicated a direct prediction effect of social support on PTG (LICI = 0.481, ULCI = 0.644), with the direct effect being 59.5%. Both positive PsyCap and perceived stress exerted a mediating role in the… More >