Jian-lin Yang*1, Ye Qin*1, Liang Li†, Chu-yu Cao*, Qing Wang*, Qian Li*, Ya-feng Lv*, Yanlin Wang*
Oncology Research, Vol.23, No.1-2, pp. 79-86, 2015, DOI:10.3727/096504015X14478843952942
Abstract In the process of tumor cell apoptosis induced by specific regents, calreticulin (CRT) was transferred from
endoplasmic reticulum (ER) onto the cell membrane. These tumor cells, when used as the cellular vaccine
to immunize experimental animals, could initiate effective antitumor immunoresponse against homologous
tumor cells. This is referred to as immunogenic cell death. Lidamycin (LDM) is an enediyne antibiotic, which
has extremely potent cytotoxicity to cancer cells. In this study, the mouse melanoma B16-F1 cancer cells were
used to investigate the ability of LDM in promoting immunogenic cell death. Our data showed that LDM could… More >
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