Chenyu Liang1, Bo Zeng2, Mai Tanaka3, Andrea Kannita Noy1, Matthew Barrett1, Erica Hengartner1, Abygale Cochrane4, Laura Garzon1, Mitchell Litvinov5, Dietmar Siemann3, Xin Tang1,3,*
The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.1, pp. 1-2, 2024, DOI:10.32604/icces.2024.011126
Abstract Cancer accounts for 12.6% of all human deaths worldwide and 90% of cancer-related deaths are due to metastasis: the dissemination of invasive tumor cells from the primary tumors to other vital organs [1-3]. However, how these invasive tumor cells coordinate with each other to achieve the dissemination remains unclear. Recently we discovered that human tumor cells can initiate and transmit previously unknown long-distance (~100s m) intercellular biochemical waves in a microenvironment-mechanics-regulated manner. [4-5] In this presentation, we will present our new results on (1) the 2D/3D spatial-temporal characterization of the long-distance and the intra-/inter-cellular Ca2+ signals; More >