MENNA AL-ADL1,*, MAGDY M. YOUSSEF1, AHMED EL-SEBAIE2, SHERIF REFAAT3, AFAF EL-SAID4
Oncology Research, Vol.32, No.4, pp. 785-797, 2024, DOI:10.32604/or.2024.047021
- 20 March 2024
Abstract Cytochromes P450 (CYPs) play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75% of the total metabolism of commercially available drugs, including chemotherapeutics. The gene expression and enzyme activity of CYPs are variable between individuals, which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics, as well as differences in the efficacy and toxicity of clinically used drugs. This research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients, as well as the clinical outcome after… More >
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