Hongsheng Dang, Wuzhou Wu, Bo Wang, Cao Cui, Juwei Niu, Jie Chen, Ziqiu Chen, Yi Liu
Oncology Research, Vol.25, No.2, pp. 177-186, 2017, DOI:10.3727/096504016X14732772150343
Abstract CXCL5, a CXC-type chemokine, is an important attractant for granulocytic immune cells by binding to its
receptor CXCR2. Recently, CXCL5/CXCR2 has been found to play an oncogenic role in many human cancers.
However, the exact role of CXCL5 in osteosarcoma cell migration and invasion has not been revealed. Here we
found that the protein expression of CXCL5 was significantly increased in osteosarcoma tissues compared with
that in matched adjacent nontumor tissues. Moreover, the expression of CXCL5 was significantly associated
with advanced clinical stage and metastasis. Further investigation showed that the CXCL5 expression levels
were also… More >
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