Kun Fan^1,2, Xiaofu Qiu², Yu Fu², Kangjian Lin, Huanhui Li², Guosheng Yang ^*,1,2

Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 33-45, 2017, DOI:10.3970/mcb.2017.014.035

Abstract This study intends to investigate the role of amentoflavone(AF) in human clear-cell renal cell carcinoma (ccRCC) and to elucidate underlying molecular mechanisms. Materials and Methods: Human RCC cell lines Caki-1 and 786-O were used in this study. Cell proliferation, apoptosis, cell cycle distribution and invasion assays were conducted to analyze the effect of AF against ccRCC in vitro. Xenograft model and pulmonary metastasis animal model were established to evaluate the vivo therapeutic efficacy and against pulmonary metastasis ability of AF, respectively. Results: Our findings revealed that AF selectively suppressed tumor cell proliferation in a dose- and time-dependent manner. Treatment with… More >

Abhishek M. Thote^1,*, Rashmi V. Uddanwadiker¹, Krishna Sharma², Sunita Shrivastava²

Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 1-17, 2017, DOI:10.3970/mcb.2017.014.001

Abstract The objective of this study was to devise an optimum force system to achieve en-masse retraction of six maxillary anterior teeth in lingual orthodontics (LiO). First, the set of equations was developed based on the mathematical computation to estimate optimum parameters of force system. Then, the computer software based on this mathematical computation was developed for the ease of estimation of force system. The verification of force system obtained with computer software was accomplished by three-dimensional finite element analysis (FEA). In FEA, it was clear that the desired en-masse retraction of six maxillary anterior teeth in LiO was achieved as… More >

Mingzhi Luo^1,2, Peili Yu¹, Yang Jin³, Zhili Qian¹, Yue Wang¹, Jingjing Li¹, Peng Shang^2*, Linhong Deng^1*

Molecular & Cellular Biomechanics, Vol.13, No.2, pp. 137-157, 2016, DOI:10.3970/mcb.2016.013.155

Abstract Random positioning machine (RPM) and diamagnetic levitation are two essential ground-based methods used to stimulate the effect of microgravity in space life science research. However, the force fields generated by these two methods are fundamentally different, as RPM generates a dynamic force field acting on the surface in contact with supporting substrate, whereas diamagnetic levitation generates a static force field acting on the whole body volume of the object (e.g. cell). Surprisingly, it is hardly studied whether these two fundamentally different force fields would cause different responses in mammalian cells. Thus we exposed cultured MC3T3-E1 osteoblasts to either dynamically stimulated… More >

Mahesh B. Mawale^1,*, Abhaykumar Kuthe², Dr. Padma Pawane³, Sandeep W. Dahake², Jyotilal S²

Molecular & Cellular Biomechanics, Vol.13, No.2, pp. 105-114, 2016, DOI:10.3970/mcb.2016.013.119

Abstract Purpose: The main purpose of this study is to develop a device for the indicative measurement of intraocular pressure (IOP) of eyeball, a key cause for glaucoma. In early diagnosis and treatment of glaucoma accurate measurement of IOP is important. The methods and devices which are available for the measurement of IOP have their own limitations which cause discomfort to the patients during measurement and needs anesthesia. There is a dare need of a device for the measurement of intraocular pressure by making the contact of plunger with closed eyelid eliminating the need of anesthesia and expert ophthalmologist. Method: Additive… More >

Longling Fan^1,§, Jing Yao^2,§, Chun Yang³, Di Xu², Dalin Tang^1,4*

Molecular & Cellular Biomechanics, Vol.13, No.1, pp. 33-55, 2016, DOI:10.3970/mcb.2016.013.044

Abstract Modeling ventricle active contraction based on in vivo data is extremely challenging because of complex ventricle geometry, dynamic heart motion and active contraction where the reference geometry (zero-stress geometry) changes constantly. A new modeling approach using different diastole and systole zero-load geometries was introduced to handle the changing zero-load geometries for more accurate stress/strain calculations. Echo image data were acquired from 5 patients with infarction (Infarct Group) and 10 without (Non-Infarcted Group). Echo-based computational two-layer left ventricle models using one zero-load geometry (1G) and two zero-load geometries (2G) were constructed. Material parameter values in Mooney-Rivlin models were adjusted to match… More >

Jianhang Du^1,2,3, Liang Wang⁴

Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 249-263, 2015, DOI:10.3970/mcb.2015.012.249

Abstract Growing evidences suggest that long-term enhanced external counterpulsation (EECP) treatment can inhibit the initiation of atherosclerotic lesion by improving the hemodynamic environment in aortas. However, whether this kind procedure will intervene the progression of advanced atherosclerotic plaque remains elusive and causes great concern in its clinical application presently. In the current paper, a pilot study combining animal experiment and numerical simulation was conducted to investigate the acute mechanical stress variations during EECP intervention, and then to assess the possible chronic effects. An experimentally induced hypercholesterolemic porcine model was developed and the basic hemodynamic measurement was performed in vivo before and… More >

Ajith Rajapaksha^1,2, Michael Fink¹, Brian A. Todd¹

Molecular & Cellular Biomechanics, Vol.12, No.3, pp. 215-230, 2015, DOI:10.3970/mcb.2015.012.215

Abstract Delivery of therapeutic agents to the eye requires efficient transport through cellular and extracellular barriers. We evaluated the rate of diffusive transport in excised porcine corneal stroma using fluorescently labeled dextran molecules with hydrodynamic radii ranging from 1.3 to 34 nm. Fluorescence correlation spectroscopy (FCS) was used to measure diffusion coefficients of dextran molecules in the excised porcine corneal stroma. The preferential sensitivity of FCS to diffusion along two dimensions was used to differentially probe diffusion along the directions parallel to and perpendicular to the collagen lamellae of the corneal stroma. In order to develop an understanding of how size… More >

Xiaozhong Chen^∗,†, Kunjin He^∗, Zhengming Chen^∗,‡, Wei Xiang^§

Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 123-146, 2015, DOI:10.3970/mcb.2015.012.123

Abstract To facilitate the modifying of femoral surface model, by dividing the femoral mesh into surface feature units bearing medical significance based on surface feature technology, a new approach of constructing femoral models using surface feature technology is proposed. Firstly, considering of femoral anatomy, the femoral triangle mesh model generated from the averaged point-clouds is divided into several specific regions, which are called feature regions; Secondly, feature parameters are defined and the constraints among them are set up, and feature surfaces are created by skinning the contours; Finally, the adjacent feature surfaces are connected by transition surfaces, and the parametric CAD… More >

Hongjian Wang^*, Jie Zheng^†, LiangWang^‡, Akiko Maehara^§, Chun Yang^II, David Muccigrosso^†, Richard Bachk^II, Jian Zhu^**, Gary S. Mintz^§, Dalin Tang^*,‡,††

Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 107-122, 2015, DOI:10.3970/mcb.2015.012.107

Abstract Computational modeling has been used extensively in cardiovascular and biological research, providing valuable information. However, 3D vulnerable plaque model construction with complex geometrical features and multicomponents is often very time consuming and not practical for clinical implementation. This paper investigated if 2D atherosclerotic plaque models could be used to replace 3D models to perform correlation analysis and achieve similar results. In vivo intravascular ultrasound (IVUS) coronary plaque data were acquired from a patient follow-up study to construct 2D structure-only and 3D FSI models to obtain plaque wall stress (PWS) and strain (PWSn) data. One hundred and twenty-seven (127) matched IVUS… More >

Francesca Cosmi^*

Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 87-105, 2015, DOI:10.3970/mcb.2015.012.087

Abstract Bone tissue is a complex multi-scale material and its morphological and functional characteristics are influenced during one’s life by constant changes, physiological and pathological. A recent technique can classify the mechanical response of trabecular bone by simulating the application of loads with a Cell Method model derived from plane radiographic images of the proximal epiphyses in the patient’s hand fingers, thus complementing the individual assessment with a low cost exam. The mesoscale pathological modifications (i.e. due to osteoporosis) can be detected and quantified, despite the simplification due to the use of radiograms. In this work, this approach is validated using… More >