Xiao-hui Sun*, Wen-jie Fan†, Zong-jian An‡, Yong Sun‡
Oncology Research, Vol.28, No.1, pp. 95-102, 2020, DOI:10.3727/096504019X15742472027401
Abstract Long noncoding RNA CRNDE (CRNDE) recently emerged as a carcinogenic promoter in various cancers
including medulloblastoma. However, the functions and molecular mechanisms of CRNDE to the acquired
drug resistance of medulloblastoma are still unclear. The transcript levels of CRNDE were examined in four
medulloblastoma cell lines exposed to cisplatin treatment, and IC50 values were calculated. Effects of CRNDE
knockdown or miR-29c-3p overexpression on cell viability, colony formation, apoptosis, migration, and invasion were assessed using the CCK-8, colony formation assay, flow cytometry, and Transwell assays, respectively. RNA pulldown and RNA-binding protein immunoprecipitation (RIP) were performed to confirm the
molecular interactions between… More >
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