Shu Chen*, Lianhua Jin†, Shu Nie†, Lizhi Han†, Na Lu†, Yan Zhou†
Oncology Research, Vol.26, No.3, pp. 445-455, 2018, DOI:10.3727/096504017X14974834436195
Abstract Accumulating evidence indicates that microRNA-205 (miR-205) is involved in tumor initiation, development,
and metastasis in various cancers. However, its functions in neuroblastoma (NB) remain largely unclear. Here
we found that miR-205 was significantly downregulated in human NB tissue samples and cell lines. miR-205
expression was lower in poorly differentiated NB tissues and those of advanced International Neuroblastoma
Staging System stage. In addition, restoration of miR-205 in NB cells suppressed proliferation, migration, and
invasion and induced cell apoptosis in vitro, as well as impaired tumor growth in vivo. cAMP-responsive elementbinding protein 1 (CREB1) was identified as a More >
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