Vyacheslav A. Shmarov, Vladimir V. Malashchenko, Maksim E. Meniailo, Natalia D. Gazatova, Natalia M. Todosenko, Olga B. Melashchenko, Andrei G. Goncharov, Victor I. Seledtsov
European Cytokine Network, Vol.27, No.4, pp. 102-107, 2016, DOI:10.1684/ecn.2016.0385
Abstract CD3+ T lymphocytes were isolated by positive magnetic separation from the peripheral blood of
healthy donors. In the absence of any additional activating stimuli, interleukin-7 (IL-7) was shown to augment
the levels of T cells expressing CD25 activation marker both in CD4-positive and in CD4-negative effector memory
(CD45RA-CD197-)
T cell subsets, as well as in terminally differentiated (CD45RA+CD197-) T cells, without
significantly affecting the activation status of naive (CD45RA+CD197+) and central memory (CD45RA-CD197+)
T
cells. In addition, IL-7 noticeably enhanced the production of IL-2, interferon-γ (IFN-γ), and IL-10, but not IL-4,
in T cells. The direct effects… More >
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