Mohammad Reza Haghshenas1, Mohammad Javad Ashraf2, Bijan Khademi3, Abbas Ghaderi1,4, Nasrollah Erfani1, Mahboobeh Razmkhah1
European Cytokine Network, Vol.28, No.1, pp. 27-35, 2017, DOI:10.1684/ecn.2017.0388
Abstract Background: To explore the molecular mechanisms involved in pathophysiology of malignant and
benign salivary gland tumors (SGTs), we investigated main tumor-inducing chemokines and chemokine receptors,
CXCL12/CXCR4/ACKR3 (CXCR7), CXCR3/CXCL10, CCR5/CCL5, CCL21/CCR7, CCL2, CCR4, CXCR5,
CCR6, and CXCL8 in tumor tissues. Patients and methods: Parotid tissues were obtained from 30 patients with
malignant and benign SGTs. Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to determine
the mRNA expression pattern of the mentioned chemokines/chemokine receptors and immunohistochemistry
(IHC) was performed to verify the expression of CCR7. Results: Expression levels of CCR7 and CCR4 transcripts
were higher in… More >
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