Li Lv*, Jian-Qin Jia*, Jin Chen†
Oncology Research, Vol.26, No.2, pp. 201-208, 2018, DOI:10.3727/096504017X14920318811749
Abstract It is increasingly evident that various long noncoding RNAs (lncRNAs) participate in the tumorigenesis of
multiple tumors, including melanoma. lncRNAs have been validated as oncogenic factors in various tumors;
however, the potential regulatory mechanism of CCAT1 in melanoma is still unclear. The purpose of this
study was to investigate the regulation of CCAT1 on melanoma genesis. The expression of CCAT1 in melanoma tissue and cell lines was measured using qRT-PCR. Interference oligonucleotide or mimic sequences
were applied to up- or downregulate RNA expression. CCK-8 and colony formation assays were performed to
detect the proliferation capability.… More >
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